Preoperative meningioma embolization reduces perioperative blood loss: a multi-center retrospective matched case-control study. (2nd January 2023)

• Record Type: Journal Article
• Authors: Al-Mufti, Fawaz; Gandhi, Chirag D.; Couldwell, William T.; Rybkin, Ilya; Abou-Al-Shaar, Hussam; Dodson, Vincent; Amin, Anubhav G.; Wainwright, John V.; Cohen, Eric; Schmidt, Meic H.; Cole, Chad; Bowers, Christian A.
• Is Part Of: British journal of neurosurgery. Volume 37:Number 1(2023)
• Page Start: 67
• Page End: 70
• Publication Date: 2023-01-02
• Subjects: Angiography -- cost -- meningioma -- therapeutic embolization; Nervous system -- Surgery -- Periodicals; 617.48
• DOI: 10.1080/02688697.2021.1979191
• Languages: English
• ISSNs: 0268-8697

Abstract

Abstract: Background and Purpose: The utility of preoperative embolization remains controversial within the literature. Here, we evaluate whether preoperative meningioma embolization is effective in reducing intraoperative blood loss, safe to perform, and cost-effective when compared with surgical resection without preoperative embolization. Methods: Twenty-nine patients with meningiomas were matched by tumor size and location to 29 control patients with meningiomas at another institution where preoperative embolization was not practiced. The variables evaluated were pre- and post-operative hemoglobin and hematocrit levels as a measure of operative blood loss and postoperative morbidity. The additional cost of undergoing angiography and embolization was calculated from hospital charges obtained from the billing department. Results: The mean decrease in perioperative hemoglobin and hematocrit was 0.9 and 2.7, respectively, in the embolization group and 2.8 and 10.0, respectively, in the control group for a significant decrease in operative blood loss as measured by change in hematocrit and hemoglobin levels after surgery. There was no significant difference in operative blood loss when subdividing patients based on tumor location. There were no angiogram-related complications. Twenty-two of 29 patients (76%) underwent embolization of a feeding artery, whereas 7 patients underwent only a diagnostic angiogram. The mean additional charge per patient in the embolization group was $88, 767. Conclusions: Preoperative embolization was safe and effective in reducing the overall perioperative blood loss in patients undergoing meningioma resection, as measured by the change in postoperative hemoglobin and hematocrit levels. However, the cost of embolization was significant.