Multimodal Imaging Approach in a Patient with Vogt-Koyanagi-Harada-like Syndrome Due to Dabrafenib and Trametinib Use for Cutaneous Melanoma. (7th February 2023)

• Record Type: Journal Article
• Authors: Bellanca, Riccardo Francesco; Pinna, Antonio; Catania, Giovanna; Belcastro, Elena; Angi, Martina; D'Amico Ricci, Giuseppe
• Is Part Of: Ocular immunology and inflammation. Volume 31:Number 2(2023)
• Page Start: 402
• Page End: 406
• Publication Date: 2023-02-07
• Subjects: Dabrafenib -- trametinib -- cutaneous melanoma -- Vogt-Koyanagi-Harada-like syndrome -- intraocular inflammation; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2021.2025250
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To describe a case of ocular inflammation associated with dabrafenib and trametinib chemotherapy for cutaneous melanoma by using a multimodal image approach. Materials and methods: We report on a 51-year-old woman with Vogt-Koyanagi-Harada-like syndrome, which occurred while she was undergoing treatment with dabrafenib and trametinib for cutaneous melanoma. The patient complained of sudden, bilateral vision loss of 2 days' duration. Anatomical and functional improvement was observed after administration of systemic steroids and cessation of chemotherapy. Later on, 6 weeks after restarting dabrafenib, she had an episode of granulomatous anterior uveitis, which was successfully managed with topical mydriatics and steroids. Strict follow-up with multimodal imaging was performed until recovery. Conclusions: This report emphasizes the importance of strict ophthalmological follow-up with multimodal imaging in patients receiving dabrafenib and trametinib, and the need for a multidisciplinary approach in the management of ocular inflammation during chemotherapy.