A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity. Issue 15 (1st February 2023)
- Record Type:
- Journal Article
- Title:
- A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity. Issue 15 (1st February 2023)
- Main Title:
- A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity
- Authors:
- Zhang, Dan
Wang, Sifan
Yang, Fangxi
Qi, Qingrong
Li, Yanfang
Huang, Wencai - Abstract:
- Abstract : A fluorescent probe for the selective and sensitive detection of ethyl triflate, a genotoxic impurity, was developed and its application in fludarabine was demonstrated. Abstract : The responses of a reaction-based fluorescent probe BI-Py towards alkyl halide, epoxide, carbonate, sulfate, sulphonate and triflate were evaluated and the probe achieved selective detection of ethyl triflate in acetonitrile with a LOD of 1.08 μM. BI-Py exhibited great potential for detecting triflate as a genotoxic impurity in drug substances.
- Is Part Of:
- Chemical communications. Volume 59:Issue 15(2023)
- Journal:
- Chemical communications
- Issue:
- Volume 59:Issue 15(2023)
- Issue Display:
- Volume 59, Issue 15 (2023)
- Year:
- 2023
- Volume:
- 59
- Issue:
- 15
- Issue Sort Value:
- 2023-0059-0015-0000
- Page Start:
- 2130
- Page End:
- 2133
- Publication Date:
- 2023-02-01
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d2cc06221f ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 25968.xml