Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels. Issue 15 (31st January 2023)

• Record Type: Journal Article
• Authors: Rijns, Laura; Su, Lu; Maxeiner, Konrad; Morgese, Giulia; Ng, David Y. W.; Weil, Tanja; Dankers, Patricia Y. W.
• Is Part Of: Chemical communications. Volume 59:Issue 15(2023)
• Page Start: 2090
• Page End: 2093
• Publication Date: 2023-01-31
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06064g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Mannose patterning is introduced into benzene-1, 3, 5-tricarboxamide (BTA)-based supramolecular assemblies through copolymerization of fully mannosylated M3 BTA with non-functionalized nBTA, and compared to their asymmetric homopolymer counterparts (M1 and M2 BTA ). Abstract : Benzene-1, 3, 5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.