Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles. Issue 8 (7th February 2023)

• Record Type: Journal Article
• Authors: Zhang, Changjun; Wei, Tingting; Yu, Zhichen; Ding, Yuxin; Su, Weike; Xie, Yuanyuan
• Is Part Of: RSC advances. Volume 13:Issue 8(2023)
• Page Start: 4958
• Page End: 4962
• Publication Date: 2023-02-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra07398f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An unprecedented metal-free regioselective halogenation of 2 H -indazoles is reported, and not only realizes the highly selective synthesis of mono-halogenated products, but also complete poly-halogenations. Abstract : An unprecedented metal-free regioselective halogenation of 2 H -indazoles has been revealed, which not only realized the highly selective synthesis of mono-halogenated products, but also completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazoles were obtained in moderate to excellent yields. Notably, this approach features environmentally friendly solvents, mild reaction conditions, simple execution and short reaction time.