Improvement in the healing of bone fractures using a cyclodextrin/Ni-MOF nanofibers network: the development of a novel substrate to increase the surface area with desirable functional properties. Issue 9 (14th February 2023)

• Record Type: Journal Article
• Authors: Lin, Junfei; Zong, Chenyu; Chen, Baisen; Wang, Teng; Xu, Jiacheng; Du, Jiashang; Lin, Yinghao; Gu, Yuming; Zhu, Jianwei
• Is Part Of: RSC advances. Volume 13:Issue 9(2023)
• Page Start: 5600
• Page End: 5608
• Publication Date: 2023-02-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra05464g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : In this study, we describe a β-cyclodextrins (β-CDs)/Ni-based MOF (β-CDs/Ni-based MOF) network for orthopedic applications. Abstract : In this study, a β-cyclodextrins (β-CDs)/Ni-based MOF (β-CDs/Ni-based MOF) fibrous network with focus on biocompatible and biodegradable properties was used as a new material for orthopedic applications. The final products were synthesized by an efficient, rapid, and controllable electrospinning route under optimal conditions, including a flow rate of 0.3 mL g −1, applied voltage of 18 kV, and spinning distance of 20 cm. Efficient characterization by various analyzes showed that the β-CDs/Ni-based MOF fibrous nanostructures had a thermal stability at about 320 °C and homogeneous particles with a narrow size distribution. The BET analysis results showed a specific surface area of 2140 m 2 g −1 for these compounds, which facilized potential conditions needed for the application of these compounds as a new substrate to improve the healing of bone fractures. The results showed the better porosity of the β-CDs/Ni-based MOF scaffolds as an essential property, leading to higher proliferation and nutrition and oxygen delivery, resulting in more tissue regeneration. This study proposes a novel strategy for a fibrous network substrate with distinct properties for orthopedic purposes.