Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease. Issue 1 (5th January 2023)

• Record Type: Journal Article
• Authors: Gillard, Justine; Leclercq, Isabelle A.
• Is Part Of: Clinical science. Volume 137:Issue 1(2023)
• Page Start: 65
• Page End: 85
• Publication Date: 2023-01-05
• Subjects: bile acids -- enterohepatic cycle -- gut microbiota -- non alcoholic fatty liver disease -- non-alcoholic steatohepatitis; Medicine -- Periodicals; Biochemistry -- Periodicals; 616
• DOI: 10.1042/CS20220697
• Languages: English
• ISSNs: 0143-5221

Abstract

Abstract: Bile acids synthesized within the hepatocytes are transformed by gut microorganisms and reabsorbed into the portal circulation. During their enterohepatic cycling, bile acids act as signaling molecules by interacting with receptors to regulate pathways involved in many physiological processes. The bile acid pool, composed of a variety of bile acid species, has been shown to be altered in diseases, hence contributing to disease pathogenesis. Thus, understanding the changes in bile acid pool size and composition in pathological processes will help to elaborate effective pharmacological treatments. Five crucial steps along the enterohepatic cycle shape the bile acid pool size and composition, offering five possible targets for therapeutic intervention. In this review, we provide an insight on the strategies to modulate the bile acid pool, and then we discuss the potential benefits in non-alcoholic fatty liver disease.