Higher-order assemblies in immune signaling: supramolecular complexes and phase separation. Issue 9 (9th April 2021)

• Record Type: Journal Article
• Authors: Xia, Shiyu; Chen, Zhenhang; Shen, Chen; Fu, Tian-Min
• Is Part Of: Protein & cell. Volume 12:Issue 9(2021)
• Page Start: 680
• Page End: 694
• Publication Date: 2021-04-09
• Subjects: higher-order assembly -- phase separation -- signalosome -- cGAS -- inflammasome -- TCR -- BCR -- TLR -- RLR -- TNFR -- death domain -- immune signaling; Proteins -- Periodicals; Cells -- Periodicals; Cytology -- Periodicals; 572.6
• DOI: 10.1007/s13238-021-00839-6
• Languages: English
• ISSNs: 1674-800X

Abstract

Abstract: Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune cells. Higher-order assemblies have recently emerged as a central principle that governs immune signaling and, by extension, cellular communication in general. There are mainly two types of higher-order assemblies: 1) ordered, solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions, and 2) liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular interactions. This review covers key examples of both types of higher-order assemblies in major immune pathways. By placing emphasis on the molecular structures of the examples provided, we discuss how their structural organization enables elegant mechanisms of signaling regulation.