JMJD3 in the regulation of human diseases. Issue 12 (7th November 2019)

• Record Type: Journal Article
• Authors: Zhang, Xiangxian; Liu, Li; Yuan, Xia; Wei, Yuquan; Wei, Xiawei
• Is Part Of: Protein & cell. Volume 10:Issue 12(2019)
• Page Start: 864
• Page End: 882
• Publication Date: 2019-11-07
• Subjects: histone methylation -- JMJD3 -- epigenetics -- human diseases; Proteins -- Periodicals; Cells -- Periodicals; Cytology -- Periodicals; 572.6
• DOI: 10.1007/s13238-019-0653-9
• Languages: English
• ISSNs: 1674-800X

Abstract

Abstract: In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.