LGI1 encephalitis: a disease of jerks and confusion. (13th October 2016)

• Record Type: Journal Article
• Authors: Dash, Deepa; Tripathi, Madhavi; Ihtisham, Kavish; Tripathi, Manjari
• Is Part Of: BMJ case reports. Volume 2016
• Publication Date: 2016-10-13
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2016-217083
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Limbic encephalitis is a group of immune-mediated disorders that includes the classic paraneoplastic encephalitic syndrome and the recently described non-paraneoplastic autoimmune encephalitis most of which target the extracellular antigens. We present a case of 70-year-old man who presented with rapidly progressive cognitive decline and refractory faciobrachial dystonic seizures and demonstrated seropositivity for leucine-rich, glioma-inactivated protein 1 antibodies. After immunomodulation, the patient had dramatic improvement in the cognitive functioning and in seizure control.