Imipenem/cilastatin-induced acute eosinophilic pneumonia. (4th March 2016)

• Record Type: Journal Article
• Authors: Foong, Kap Sum; Lee, Ashley; Pekez, Marijeta; Bin, Wei
• Is Part Of: BMJ case reports. Volume 2016
• Publication Date: 2016-03-04
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2016-214804
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Drugs, toxins, and infections are known to cause acute eosinophilic pneumonia. Daptomycin and minocycline are the commonly reported antibiotics associated with acute eosinophilic pneumonia. In this study, we present a case of imipenem/cilastatin-induced acute eosinophilic pneumonia. The patient presented with fever, acute hypoxic respiratory distress, and diffuse ground-glass opacities on the chest CT a day after the initiation of imipenem/cilastatin. Patient also developed peripheral eosinophilia. A reinstitution of imipenem/cilastatin resulted in recurrence of the signs and symptoms. A bronchoscopy with bronchoalveolar lavage showed 780 nucleated cells/mm 3 with 15% eosinophil. The patient's clinical condition improved significantly after the discontinuation of imipenem/cilastatin therapy and the treatment with corticosteroid.