Metabolic status indicators and influencing factors in non-obese, non-centrally obese nonalcoholic fatty liver disease. Issue 6 (10th February 2023)

• Record Type: Journal Article
• Authors: Huang, Zhipeng; Wei, Donghong; Yu, Xueping; Huang, Zicheng; Lin, Yijie; Lin, Wenji; Su, Zhijun; Jiang, Jianjia
• Is Part Of: Medicine. Volume 102:Issue 6(2023)
• Page Start: e32922
• Publication Date: 2023-02-10
• Subjects: insulin resistance -- metabolic syndrome -- nonalcoholic fatty liver disease -- obesity -- visceral adiposity; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000032922
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Non-obese nonalcoholic fatty liver disease (NAFLD) is characterized by metabolic disorders and related complications. This study aimed to provide an integrated description of clinical, metabolic, and influencing factors for a specific category of patients with non-obese NAFLD. A total of 36 participants with body mass index (BMI) < 28 kg/m 2 and visceral adipose tissue < 100 cm 2 were classified into 2 groups: the non-obese, non-centrally obese control group (n = 17) and non-obese, non-centrally obese NAFLD group (n = 19). Hypertriglyceridemia, impaired fasting glucose, low high-density lipoprotein cholesterol levels, and hypertension were used to determine whether participants were metabolically abnormal. Based on a logistic regression model, odds ratios for the factors influencing NAFLD with 95% confidence intervals were calculated. Insulin resistance (IR) and fasting plasma glucose (FPG) levels were higher in the NAFLD group than in the control group ( P < .05). The NAFLD group had a higher metabolic abnormality rate than the healthy control group (36.84% vs 5.88%, P = .044). Correlation analysis showed that IR was positively correlated with FPG and triglyceride ( P < .05). BMI was the main influencing factor of NAFLD (regression coefficient β = 0.631; odds ratio = 1.879; 95% confidence interval, 1.233–2.863). NAFLD patients with a BMI < 28 kg/m 2 and visceral adipose tissue < 100 cm 2 had more apparent IR, higher FPG, and a higher metabolic abnormality rate. IR may be affected by FPG and triglyceride. Even in non-obese and non-centrally obese individuals, BMI should be controlled to avoid NAFLD.