Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success. (11th February 2023)

• Record Type: Journal Article
• Authors: Cummings, Linda C.; Hojat, Leila S.; Nguyen, David C.; Stempak, Lisa M.; Rhoads, Daniel D.; Sadri, Navid
• Is Part Of: American journal of gastroenterology. Volume 118:Number 2(2023)
• Page Start: 360
• Page End: 363
• Publication Date: 2023-02-11
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000002085
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. METHODS: In this retrospective study, we report the effect of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori . RESULTS: The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment. DISCUSSION: This is the first study describing the use of H. pylori genetic resistance testing as standard of care.