Financial Toxicity After Robot-Assisted Radical Prostatectomy and Its Relation with Oncologic, Functional Outcomes. Issue 5 (1st November 2022)

• Record Type: Journal Article
• Authors: Özman, Oktay; Tillier, Corinne N.; van Muilekom, Erik; van de Poll-Franse, Lonneke V.; van der Poel, Henk G.
• Is Part Of: Journal of urology. Volume 208:Issue 5(2022)
• Page Start: 978
• Page End: 986
• Publication Date: 2022-11-01
• Subjects: prostatic neoplasms -- financial stress -- patient reported outcome measures -- quality of life -- robotic surgical procedures; Genitourinary organs -- Periodicals; Urology -- Periodicals; Urology -- Periodicals; Urologie -- Périodiques; Urologie; 616.6
• DOI: 10.1097/JU.0000000000002897
• Languages: English
• ISSNs: 0022-5347

Abstract

Abstract : Purpose: The aim of the study was to evaluate frequency of financial toxicity among patients who underwent robot-assisted radical prostatectomy for prostate cancer. Materials and Methods: Data of 1, 479 robot-assisted radical prostatectomy patients between 2006-2021 reporting no financial toxicity in preoperative assessments were included retrospectively. Financial toxicity was measured with financial impact of European Organisation for Research and Treatment of Cancer-quality of life questionnaire-C30. Financial impact scores were collected preoperatively, 6, 12, 18, and 24 months after robot-assisted radical prostatectomy. Results: The frequency of financial toxicity was 8.3% (122/1379; 95% CI 7.0-9.8) at any point in time throughout 2 years of follow-up. Patients reporting financial toxicity (63 [58-68]) were significantly younger than patients who had no financial toxicity (65 [61-69]; P = .001). There was no statistically significant difference between financial toxicity+ and financial toxicity− groups in terms of salvage radiotherapy ( P = .8) and positive surgical margin ( P = .2) rates. In functional assessments, clinically significant International Prostate Symptom Score and International Consultation on Incontinence Questionnaire—Short Form score increase of financial toxicity+ patients (34% and 62%) were more frequent than financial toxicity− patients (23% and 47%; P = .004 and P = .002, respectively). In multivariable analysis, age at robot-assisted radical prostatectomy, International Prostate Symptom Score, International Consultation on Incontinence Questionnaire—Short Form, and quality of life scores were associated with financial toxicity ( P < .001, OR 0.95 [95% CI 0.92-0.98]; P = .015, OR 2.4 [95% CI 1.2-4.7]; P = .032, OR 1.5 [95% CI 1.2-2.5]; P = .01, OR 0.09 [95% CI 0.01-0.57], respectively). Patients who underwent robot-assisted radical prostatectomy before retirement (≤65 years) had a 1.6-fold increased financial toxicity risk ( P = .003, 95% CI 1.1-2.3). Conclusions: Financial toxicity after robot-assisted radical prostatectomy is low in mid-term follow-up. Patients who report urological symptoms after robot-assisted radical prostatectomy should also be evaluated for financial toxicity. Required measures against financial toxicity should be taken especially in the follow-up of younger cancer survivors.