Epidemiology of Gastric Intestinal Metaplasia and Gastric Cancer. Issue 1 (March 2023)

• Record Type: Journal Article
• Authors: Pham, Codey; Nguyen Wenker, Theresa; El-Serag, Hashem B
• Is Part Of: Foregut. Volume 3:Issue 1(2023)
• Page Start: 80
• Page End: 88
• Publication Date: 2023-03
• Subjects: gastric cancer -- gastric intestinal metaplasia -- epidemiology -- incidence trends -- risk factors; 616.3
• DOI: 10.1177/26345161231154024
• Languages: English
• ISSNs: 2634-5161

Abstract

Gastric cancer remains one of the most common cancers globally. The pathogenesis of intestinal-type gastric cancer involves pre-malignant stages, including gastric intestinal metaplasia (GIM), the replacement of native gastric foveolar and/or glandular epithelium by intestinal-type epithelium. GIM prevalence is highly variable based on geography and race/ethnicity partly due to the varying prevalence of H. pylori, a potent risk factor. However, gastric cancer incidence does not mirror that of H. pylori, demonstrating a complex interaction between H. pylori and risk factors. We will discuss the epidemiology of GIM and gastric cancer, including incidence trends, risk factors, and implications for future management.