Synthesis and in vitro evaluation of Ca-P coating on biodegradable Zn alloys. (1st April 2023)

• Record Type: Journal Article
• Authors: Li, Huafang; Zheng, Yixing; Ji, Xiaojing
• Is Part Of: Journal of materials science & technology. Volume 141(2023)
• Page Start: 124
• Page End: 134
• Publication Date: 2023-04-01
• Subjects: Zinc alloy -- Biodegradable metals -- Ca-P coating -- Corrosion behavior -- Biocompatibility; Metals -- Periodicals; Materials science -- Periodicals; Materials science; Metals; Periodicals; 620.1105
• DOI: 10.1016/j.jmst.2022.10.003
• Languages: English
• ISSNs: 1005-0302

Abstract

Highlights: Ca-P coating was fabricated on Zn-Mg alloy. Ca-P coating inhibits the explosive release of Zn 2+ of Zn-Mg alloy. Ca-P coating exhibits superior antibacterial activity and biocompatibility. Abstract: The burst release of Zn 2+ from the naked pure Zn and Zn-based alloys could induce local and systemic toxicity, which limits their clinical applications as biodegradable implants. In order to inhibit the explosive release of zinc ions, a protective Ca-P coating was synthesized on biodegradable Zn alloy. The microstructure, corrosion resistance, antibacterial activity, and biosafety of the Ca-P coating are systematically investigated. Electrochemical tests revealed that Ca-P protective layer has enhanced the anti-corrosion behavior of Zn alloy. Furthermore, Ca-P protective layer showed good biocompatibility, as demonstrated by significantly increased cell viability, good attachment, and spreading at a higher cell density. Besides, the Ca-P coating could also retain the antibacterial ability and inhibit the bacterial adhesion. The Ca-P protective layer synthesized on biodegradable Zn alloy can be considered and applied in future biomedical applications.