Age of onset of cerebral venous thrombosis: the BEAST study. (March 2023)

• Record Type: Journal Article
• Authors: Ranjan, Redoy; Ken-Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Le Cam Duchez, Veronique; Bagan Triquenot, Aude; Zedde, Marialuisa; Mancuso, Michelangelo; Ruigrok, Ynte M; Worrall, Brad; Majersik, Jennifer J; Putaala, Jukka; Haapaniemi, Elena; Zuurbier, Susanna M; Brouwer, Matthijs C; Passamonti, Serena M; Abbattista, Maria; Bucciarelli, Paolo; Lemmens, Robin; Pappalardo, Emanuela; Costa, Paolo; Colombi, Marina; Aguiar de Sousa, Diana; Rodrigues, Sofia; Canhao, Patrícia; Tkach, Aleksander; Santacroce, Rosa; Favuzzi, Giovanni; Arauz, Antonio; Colaizzo, Donatella; Spengos, Kostas; Hodge, Amanda; Ditta, Reina; Han, Thang S; Pezzini, Alessandro; Coutinho, Jonathan M; Thijs, Vincent; Jood, Katarina; Tatlisumak, Turgut; Ferro, José M; Sharma, Pankaj;
• Is Part Of: European stroke journal. Volume 8:Number 1(2023)
• Page Start: 344
• Page End: 350
• Publication Date: 2023-03
• Subjects: Cerebral venous thrombosis -- cerebral venous sinus thrombosis -- age of onset -- women; Cerebrovascular disease -- Periodicals; 616.8005
• DOI: 10.1177/23969873221148267
• Languages: English
• ISSNs: 2396-9873

Abstract

Background: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset. Methods: We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females. Results: A total of 1309 CVT patients (75.3% females) aged ⩾18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35–58) years and 37 (28–47) years ( p < 0.001), respectively. However, the presence of antibiotic-requiring sepsis ( p = 0.03, 95% CI 27–47 years) among males and gender-specific risk factors like pregnancy ( p < 0.001, 95% CI 29–34 years), puerperium ( p < 0.001, 95% CI 26–34 years) and oral contraceptive use ( p < 0.001, 95% CI 33–36 years) were significantly associated with earlier onset of CVT among females. CFA demonstrated a significantly earlier onset of CVT in females, ~12 years younger, in those with multiple (⩾1) compared to '0' risk factors ( p < 0.001, 95% CI 32–35 years). Conclusions: Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (⩾1) risk factors suffer CVT ~12 years earlier compared to those with no identifiable risk factors.