Host genetic variability and determinants of severe COVID-19. Issue 3 (March 2023)

• Record Type: Journal Article
• Authors: Brest, Patrick; Mograbi, Baharia; Gal, Jocelyn; Hofman, Paul; Milano, Gerard
• Is Part Of: Trends in genetics. Volume 39:Issue 3(2023)
• Page Start: 169
• Page End: 171
• Publication Date: 2023-03
• Subjects: SARS-CoV-2 -- COVID-19 -- germinal genetics -- interferon -- ACE2; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2022.10.003
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract: Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, convergent studies have provided evidence that host genetic background may contribute to the development of severe coronavirus disease (COVID-19). Here, we summarize how some genetic variations, such as in SARS-CoV-2 receptor angiotensin-converting enzyme 2 or interferon signaling pathway, may help to understand why some individuals can develop severe COVID-19.