Performance assessment of electrode configurations for the estimation of omnipolar electrograms from high density arrays. (March 2023)

• Record Type: Journal Article
• Authors: Castells, Francisco; Ruipérez-Campillo, Samuel; Segarra, Izan; Cervigón, Raquel; Casado-Arroyo, Rubén; Merino, José Luis; Millet, José
• Is Part Of: Computers in biology and medicine. Volume 154(2023)
• Publication Date: 2023-03
• Subjects: High density electrode arrays -- Omnipolar electrograms -- Signal processing -- Robust electrogram estimation -- Electrophysiology -- Biomedical engineering; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2023.106604
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Objective: The aim of this study is to propose a method to reduce the sensitivity of the estimated omnipolar electrogram (oEGM) with respect to the angle of the propagation wavefront. Methods: A novel configuration of cliques taking into account all four electrodes of a squared cell is proposed. To test this approach, simulations of HD grids of cardiac activations at different propagation angles, conduction velocities, interelectrode distance and electrogram waveforms are considered. Results: The proposed approach successfully provided narrower loops (essentially a straight line) of the electrical field described by the bipole pair with respect to the conventional approach. Estimation of the direction of propagation was improved. Additionally, estimated oEGMs presented larger amplitude, and estimations of the local activation times were more accurate. Conclusions: A novel method to improve the estimation of oEGMs in HD grid of electrodes is proposed. This approach is superior to the existing methods and avoids pitfalls not yet resolved. Relevance: Robust tools for quantifying the cardiac substrate are crucial to determine with accuracy target ablation sites during an electrophysiological procedure. Highlights: A robust method to estimate Omnipolar Electrograms is proposed for HD catheters. A novel methodology based on a cross-oriented clique is proposed for the first time. The direction of propagation is better estimated. Local activation times are detected with higher accuracy. Results may have a big impact on the design of novel catheters.