Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance. (March 2023)

• Record Type: Journal Article
• Authors: Guo, Xu; Gao, Congying; Yang, Dong-Hua; Li, Shenglong
• Is Part Of: Drug resistance updates. Volume 67(2023)
• Publication Date: 2023-03
• Subjects: OS overall survival -- MDR multidrug resistance -- TME tumor microenvironment -- circRNA Circular RNA -- pre-mRNA precursor mRNA -- RNase RNA exonuclease or ribonuclease -- EVs Extracellular vesicles -- MVBs multivesicular bodies -- TMZ temozolomide -- NGS next generation sequencing -- RBPs RNA binding proteins -- IRES internal ribosome entry site -- EMT epithelial-mesenchymal transition -- DOX azithromycin -- TACE transarterial chemoembolization -- CAFs cancer-associated fibroblasts -- OXA oxaliplatin -- GEM gemcitabine -- NSCLC non-small cell lung cancer -- LNM lymph node metastasis -- DM distant metastasis -- PTX paclitaxel -- LR lapatinib-resistant -- PFS progression-free survival -- MDSCs myeloid-derived suppressor cells; Exosome -- Circular RNA (circRNA) -- Chemotherapy resistance -- Cancer; Drug resistance in cancer cells -- Periodicals; Cancer -- Chemotherapy -- Periodicals; 616.994061
• DOI: 10.1016/j.drup.2023.100937
• Languages: English
• ISSNs: 1368-7646

Abstract

Abstract: Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired drug resistance hinders clinical efficacy and leads to treatment failure in most patients. Exosomes are cell-derived vesicles with a diameter of 30–150 nm carrying and delivering substances such as DNAs, RNAs, lipids, and proteins for cellular communication in tumor development. Circular RNAs (circRNAs) present covalently closed-loop RNA structures, which regulate tumor cell proliferation, apoptosis, and metastasis by controlling different genes and signaling pathways. CircRNAs are abundant and stably expressed in exosomes. Recent studies have shown that they play critical roles in chemotherapy resistance in various cancers. In this review, we summarized the origin of exosomes and discussed the regulation mechanism of exosomal circRNAs in cancer drug resistance.