Bacterial cellulose-based hydrogel with antibacterial activity and vascularization for wound healing. (15th May 2023)

• Record Type: Journal Article
• Authors: Deng, Lili; Huang, Yinjun; Chen, Shiyan; Han, Zhiliang; Han, Zhengzhe; Jin, Mengtian; Qu, Xiangyang; Wang, Baoxiu; Wang, Huaping; Gu, Song
• Is Part Of: Carbohydrate polymers. Volume 308(2023)
• Publication Date: 2023-05-15
• Subjects: Bacterial cellulose -- Metal-organic framework (MOF) -- Photothermal -- Antibacterial activity -- Angiogenesis activity -- Wound healing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2023.120647
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Skin wounds need an appropriate wound dressing to help prevent bacterial infection and accelerate wound closure. Bacterial cellulose (BC) with a three-dimensional (3D) network structure is an important commercial dressing. However, how to effectively load antibacterial agents and balance the antibacterial activity is a lingering issue. Herein, this study aims to develop a functional BC hydrogel containing silver-loaded zeolitic imidazolate framework-8 (ZIF-8) antibacterial agent. The tensile strength of the prepared biopolymer dressing is >1 MPa, the swelling property is over 3000 %, the temperature can reach 50 °C in 5 min with near-infrared (NIR) and the release of Ag + and Zn 2+ is stable. In vitro investigation shows that the hydrogel displays enhanced antibacterial activity, and the bacteria survival ratios are only 0.85 % and 0.39 % against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). In vitro cell experiments present that BC/polydopamine/ZIF-8/Ag (BC/PDA/ZIF-8/Ag) shows satisfactory biocompatibility and promising angiogenic ability. In vivo study, the full-thickness skin defect on rats demonstrates remarkably wound healing ability and accelerated skin re-epithelialization. This work presents a competitive functional dressing with effective antibacterial properties and accelerative angiogenesis activities for wound repair. Graphical abstract: Unlabelled Image