Synthesis, structures, antioxidant, and antifungal activities of organotin(IV) complexes derived from 1-(3′-carboxyphenylhydrazono)naphthalene-2-one. Issue 19 (17th December 2022)

• Record Type: Journal Article
• Authors: Debnath, Pratima; Debnath, Paresh; Devi, Th. Sonia; Singh, S. Suresh Kumar; Bhattacharya, Arnab; Singh, Keisham Surjit; Roy, Manojit; Misra, Tarun Kumar
• Is Part Of: Journal of coordination chemistry. Volume 75:Issue 19-24(2022)
• Page Start: 3015
• Page End: 3032
• Publication Date: 2022-12-17
• Subjects: Organotin(IV) compounds -- crystal structures -- NMR spectroscopy -- antioxidant -- antifungal agent; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2022.2155145
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: In this study, the hydrazone ligand 1-(3′-carboxyphenylhydrazono)naphthalene-2-one (H2 L) was employed to generate three new organotin(IV) compounds with the general formula of [R x Sn IV (HL) y ] (where R = Me, x = y = 2 (1 ); R = n -Bu, x = 3, y = 1 (2 ), and R = Ph, x = 3, y = 1 (3 )). The single-crystal structures of 1 and 3 were examined to establish the coordination environment about Sn(IV). Compound 1 possesses a hepta -coordinate homo-polymer with a chromophoric coordination environment of Me2 Sn IV O5 . Compound 3, on the other hand, has monomeric distorted tetrahedral geometry with Ph3 SnO chromophoric unit. The 119 Sn-NMR signals in the spectra of 1–3 are found to be at 145.5, 120.1, and −104.4 ppm, respectively, indicating that they are isostructural and adopt four-coordinate tetrahedral geometry in solution. The bioactivities of 1 and 3 among the three are distinct. The antioxidant activity of 1 in ethanol is the highest, with a 45.64% DPPH-scavenging efficiency, whereas 3 shows excellent antifungal efficacy against Penicilium chrysogenum, with a 21 mm inhibited zone at 750 μg/mL, which is significantly higher than that of standard drug amphotericin-B. Thus, the compounds could be treated as potential antioxidant and antifungal agents. Abstract : UF0001