Aceclofenac-induced acute tubulointerstitial nephritis in a patient with diabetes. (15th May 2013)

• Record Type: Journal Article
• Authors: Gupta, Monica; Cruz, Sanjay D; Nada, Ritambhara; Aggarwal, Purnima
• Is Part Of: BMJ case reports. Volume 2013
• Publication Date: 2013-05-15
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2013-009217
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : We describe a case of a 40-year-old lady diabetic and hypertensive, who presented with increasing fatigue and decreased physical endurance attributable to deterioration in renal function. The renal biopsy revealed drug-induced acute tubulointerstitial nephritis and the chronology of the events suggested the aetiology to be a recent intake of aceclofenac for knee pain. The patient improved with oral corticosteroids and the renal functions returned to baseline in 3 weeks. We did not come across a case of aceclofenac-induced acute tubulointerstitial nephritis on extensive electronic search of literature. This is probably the first case report of acute tubulointerstitial nephritis associated with the use of aceclofenac, a newer potent non-steroidal anti-inflammatory drug.