[3+2] Cycloaddition of Nitrile Imines with 3‐Benzylidene Succinimides: A Facile Access to Functionalized Spiropyrazolines. Issue 2 (27th January 2022) - Yuan, Cheng
Abstract: A wide range of substituted spiro‐pyrazoline derivatives containing the pyrrolidinone core have been prepared by alkalic treatment of 3‐benzylidene succinimides and nitrile imines. All reactions proceeded under mild conditions and the products were isolated by column chromatography in good yields with high diastereoselectivity. Furthermore, this method featured several advantages such as good functional group tolerance and simple scalability. Abstract : Spiro‐pyrazoline was obtained from 2‐arylmethylene maleimide and nitrile imide by metal‐free catalytic construction of pyrazoline ring in CS2 CO3 condition with good yield. This reaction has good scalability and tolerance.