Direct C−H Difluoroalkylation of Heteroarenes with Difluoroalkyl Carboxylic Acids. Issue 1 (2nd December 2021)

• Record Type: Journal Article
• Authors: Guo, Chunfang; Han, Xuliang; Li, Xiangye; Diao, Zhengzhen; Li, Xinjin; Dong, Yunhui
• Is Part Of: Asian journal of organic chemistry. Volume 11:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-02
• Subjects: difluoroalkylation -- silver-catalyzed -- C−H functionalization -- heteroarenes -- difluoroalkyl carboxylic acid; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100663
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A new method for the difluoroalkylation of heteroaromatic compounds has been developed by employing readily available difluoroalkyl carboxylic acids. This silver‐catalyzed reaction proceeds under mild conditions and affords a broad range of difluoroalkylated heteroarenes in moderate to good yields, including pyridines, pyrimidines, pyrazines, quinolines, quinoxalines as well as bioactive compounds. Abstract : Difluoroalkylation : The direct C−H difluoroalkylation of heteroarenes with difluoroalkyl carboxylic acids has been successfully developed. This method exhibits good tolerance to functional groups, providing a general access to (difluoroalkyl)heteroarenes.