Cover Picture: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. Int. Ed. 10/2022). Issue 10 (8th February 2022)

• Record Type: Journal Article
• Authors: Cao, Wenyue; Geng, Zhi Zachary; Wang, Na; Pan, Quan; Guo, Shaodong; Xu, Shiqing; Zhou, Jianfeng; Liu, Wenshe Ray
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-08
• Subjects: asunaprevir -- CAR-T therapy -- chemical switches -- chimeric antigen receptors -- NS3 protease; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202201860
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Chimeric antigen receptor (CAR) T cell therapy suffers from complications including cytokine release syndromes and T cell exhaustion. To curb these drawbacks, Jianfeng Zhou, Wenshe Ray Liu et al. report in their Research Article (e202109550) a chemogenetic switch that can be reversibly turned on and off to control the expression of CAR using a clinically approved small‐molecule drug, asunaprevir. This novel technique will potentially enable delicate modulation of CAR‐T activation during cancer treatment.