A Facile Route to Pyrazolo[1, 2‐a]cinnoline via Rhodium(III)‐catalyzed Annulation of Pyrazolidinoes and Iodonium Ylides. Issue 1 (1st December 2021)

• Record Type: Journal Article
• Authors: Yang, Zi; Zhou, Yi; Li, Haigang; Lei, Jieni; Bing, Pingping; He, Binsheng; Li, Yaqian
• Is Part Of: Asian journal of organic chemistry. Volume 11:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-01
• Subjects: pyrazolidione -- pyrazolo[1, 2-a]cinnoline -- iodonium ylide -- cascade reaction -- C−H bond functionalization; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100656
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A rhodium(III)‐catalysed cascade C−H bond activation/intramolecular cyclization of pyrazolidiones with iodonium ylide has been described, leading to the formation of various pyrazolo[1, 2‐a]cinnolines. Herein, iodonium ylide serves as a carbene precursor. This protocol exhibits good regioselectivity and high functional group tolerability under mild reaction conditions. Abstract : A simple and efficient procedure to pyrazolo[1, 2‐a]cinnoline starting from easily available pyrazolidiones and iodonium ylide via a rhodium‐catalyzed [4+2] annulative coupling reaction is presented.