Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course. (19th September 2013)

• Record Type: Journal Article
• Authors: Patel, Pratik Nalinbhai; Mutalik, Vimi Sunil; Rehani, Shweta; Radhakrishnan, Raghu
• Is Part Of: BMJ case reports. Volume 2013
• Publication Date: 2013-09-19
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2013-200441
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Basaloid squamous cell carcinoma (BSCC) is a rare variant of SCC having a marked predilection for the upper aerodigestive tract. It is regarded as a high-grade tumour with increased propensity for metastasis to distant sites. The histological hallmark of BSCC is its dimorphic pattern of presentation with a characteristic basal cell component associated with squamous component. We report two cases of BSCC on the buccal mucosa and gingiva, respectively, with the former presenting as a primary lesion in a patient without a positive history of tobacco and alcohol use and the latter present as a seemingly metachronous development from carcinoma lung. The proliferative index of the two diverse yet similar entities was assessed by Ki-67 labelling index (LI) and the association of human papillomavirus (HPV) was detected with p16 monoclonal antibody. The intrinsically aggressive behaviour of BSCC and its association with HPV is highlighted.