Acute kidney injury in Japanese type 2 diabetes patients receiving sodium–glucose cotransporter 2 inhibitors: A nationwide cohort study. Issue 1 (2nd August 2021)

• Record Type: Journal Article
• Authors: Horii, Takeshi; Oikawa, Yoichi; Kunisada, Narumi; Shimada, Akira; Atsuda, Koichiro
• Is Part Of: Journal of diabetes investigation. Volume 13:Issue 1(2022)
• Page Start: 42
• Page End: 46
• Publication Date: 2021-08-02
• Subjects: Acute kidney injury -- Risk factors -- Sodium–glucose cotransporter 2 inhibitors; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13630
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: The present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors. We identified 171, 622 patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors; among them, 476 (0.3%) patients developed acute kidney injury. The hazard ratio for acute kidney injury occurrence risk was analyzed using a Cox proportional hazards model adjusted for patient characteristics at baseline and use of concomitant agents. In the adjusted model, patients who developed acute kidney injury were mostly men, aged ≥65 years, had lower body mass index, had a history of heart failure and used diuretics more frequently than those who did not. These findings suggest that associated clinical risk factors should be thoroughly evaluated before administering sodium–glucose cotransporter 2 inhibitors to minimize acute kidney injury onset. Abstract : BLURB FOR ETOC: AKI risk associated with SGLT2 inhibitors