Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation. Issue 4 (1st October 2021)

• Record Type: Journal Article
• Authors: Avenoso, Daniele; Krishnamurthy, Pramila; Salisbury, Jonathan; Rashid, Sabia; Gandhi, Shreyans
• Is Part Of: EJHaem. Volume 2:Issue 4(2021)
• Page Start: 899
• Page End: 900
• Publication Date: 2021-10-01
• Subjects: Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.289
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts.