Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy. (18th November 2015)

• Record Type: Journal Article
• Authors: Hirst, Claire L; Willis, Mark; Hussain, Hussain; Powell, Rob
• Is Part Of: BMJ case reports. Volume 2015
• Publication Date: 2015-11-18
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2015-209556
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Neurological involvement at onset in acute myeloid leucaemia (AML) is rare, with only a few isolated case reports. We present the case of a 46-year-old man with rapidly progressive polyradiculoneuropathy as the presenting feature of AML. The proposed mechanism for this is postulated to be direct intraneural infiltration, although a paraneoplastic, autoimmune-related phenomenon could be possible. Despite chemotherapeutic intervention, the patient died 1 month after initial presentation. Although rare, neurological manifestations of AML do occur and it is important to include haematological malignancies in the differential diagnosis in patients presenting with neurological symptoms.