Assessment of Protective Effects of Pheniramine Maleate on Reperfusion Injury in Lung After Distant Organ Ischemia: A Rat Model. (April 2013)

• Record Type: Journal Article
• Authors: Gokalp, Orhan; Yurekli, Ismail; Kiray, Muge; Bagriyanik, Alper; Yetkin, Ufuk; Yurekli, Banu Sarer; Gur, Serkan; Aksun, Murat; Satoglu, Ismail Safa; Gokalp, Gamze; Gurbuz, Ali
• Is Part Of: Vascular & endovascular surgery. Volume 47:Number 3(2013)
• Page Start: 219
• Page End: 224
• Publication Date: 2013-04
• Subjects: ischemia/reperfusion injury -- pheniramine maleate -- lung; Blood-vessels -- Surgery -- Periodicals; Blood-vessels -- Endoscopic surgery -- Periodicals; Vascular Surgical Procedures -- Periodicals; Angioplasty -- Periodicals; Surgical Procedures, Minimally Invasive -- Periodicals; Vascular Diseases -- surgery -- Periodicals; Vaisseaux sanguins -- Chirurgie -- Périodiques; Vaisseaux sanguins -- Chirurgie endoscopique -- Périodiques; 617.41
• DOI: 10.1177/1538574413475885
• Languages: English
• ISSNs: 1538-5744

Abstract

Objective: The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats. Materials and methods: A total of 28 randomly selected male rats were divided into 4 groups, each consisting of 7 rats. Group 1 was the control group. Group 2 was the sham group (ischemia/reperfusion [I/R]). Rats in group 3 were subjected to I/R and given PM (Ph group) and rats in group 4 were subjected to I/R and given MP (Pn group). Results: Malondialdehyde levels were significantly lower in Ph group than in I/R group ( P < .05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in Ph group than in the I/R group ( P < .05). Histological examination demonstrated that PM had protective effects against I/R injury. Conclusions: The PM has a protective effect against I/R injury in rat lung.