Aptamer‐based biosensors and application in tumor theranostics. Issue 1 (16th November 2021)

• Record Type: Journal Article
• Authors: Mo, Tong; Liu, Xiyu; Luo, Yiqun; Zhong, Liping; Zhang, Zhikun; Li, Tong; Gan, Lu; Liu, Xiuli; Li, Lan; Wang, Huixue; Sun, Xinjun; Fan, Dianfa; Qian, Zhangbo; Wu, Pan; Chen, Xiaoyuan
• Is Part Of: Cancer science. Volume 113:Issue 1(2022)
• Page Start: 7
• Page End: 16
• Publication Date: 2021-11-16
• Subjects: colorimetric aptasensor -- electrochemical aptasensor -- fluorescent aptasensor -- tumor diagnosis -- tumor marker; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.15194
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract: An aptamer is a short oligonucleotide chain that can specifically recognize targeting analytes. Due to its high specificity, low cost, and good biocompatibility, aptamers as the targeting elements of biosensors have been applied widely in non‐invasive tumor imaging and treatment in situ to replace traditional methods. In this review, we will summarize recent advances in using aptamer‐based biosensors in tumor diagnosis. After a brief introduction of the advantage of aptamers compared with enzyme sensors and immune sensors, the different sensing designs and mechanisms based on 3 signal transduction modes will be reviewed to cover different kinds of analytical methods, including: electrochemistry analysis, colorimetry analysis, and fluorescence analysis. Finally, the prospective advantages of aptamer‐based biosensors in tumor theranostics and post‐treatment monitoring are also evaluated in this review. Abstract : This review introduces the advantages of aptamer sensors in disease diagnosis compared with traditional biosensors. It also shows the design strategies of the 3 most studied aptamer sensors: fluorescent aptasensors, electrochemical aptasensors, and colorimetric aptasensors, and their application in early tumor diagnosis. Moreover, taking the fluorescent aptasensor as an example, the design of aptasensors combined with nanomaterials can not only be used for tumor imaging, but also has important significance in tumor treatment and efficacy evaluation. The design provides a new idea for the integration of tumor theranostics.