Artemisinin Combination Therapy Can Result in Clinical Failure If Oral Therapy Is Not Directly Observed. Issue 4 (2013)

• Record Type: Journal Article
• Authors: Chan, Wilson W; Virmani, Divya; Pillai, Dylan R
• Is Part Of: Canadian journal of infectious diseases & medical microbiology =. Volume 24:Issue 4(2013)
• Page Start: 215
• Page End: 216
• Publication Date: 2013
• Subjects: Communicable diseases -- Periodicals; Infection -- Periodicals; Communicable diseases; Infection; Communicable Diseases; Communicable Disease Control; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.9
• DOI: 10.1155/2013/427910
• Languages: English
• ISSNs: 1712-9532

Abstract

Abstract : Intravenous artesunate therapy is the first-line therapy for severe malaria, and is highly efficacious when used in combination with an oral partner drug such as doxycycline or atovaquone-proguanil. However, treatment failure occurs routinely with artesunate monotherapy due to the very short half-life of this drug. In North America, experience with artesunate is limited. With the pressure to discharge patients early, administration of the essential oral partner drug is often left to the discretion of the patient. Thus, treatment failure may be commonplace if nonadherence is a factor, as was observed in the case described in the present report.