HIV-1 Tropism Testing and Clinical Management of CCR5 Antagonists: Quebec Review and Recommendations. Issue 4 (2013)

• Record Type: Journal Article
• Authors: Tremblay, Cécile; Hardy, Isabelle; Lalonde, Richard; Trottier, Benoit; Tsarevsky, Irina; Vézina, Louis-Philippe; Roger, Michel; Wainberg, Mark; Baril, Jean-Guy
• Is Part Of: Canadian journal of infectious diseases & medical microbiology =. Volume 24:Issue 4(2013)
• Page Start: 202
• Page End: 208
• Publication Date: 2013
• Subjects: Communicable diseases -- Periodicals; Infection -- Periodicals; Communicable diseases; Infection; Communicable Diseases; Communicable Disease Control; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.9
• DOI: 10.1155/2013/982759
• Languages: English
• ISSNs: 1712-9532

Abstract

Abstract : HIV-1 tropism assays play a crucial role in determining the response to CCR5 receptor antagonists. Initially, phenotypic tests were used, but limited access to these tests prompted the development of alternative strategies. Recently, genotyping tropism has been validated using a Canadian technology in clinical trials investigating the use of maraviroc in both experienced and treatment-naive patients. The present guidelines review the evidence supporting the use of genotypic assays and provide recommendations regarding tropism testing in daily clinical management.