Successful Bone Marrow Transplantation With Intensive Post-transplant Intrathecal Chemotherapy for CNS Relapsed AML in 2 Infants. Issue 1 (8th April 2021)

• Record Type: Journal Article
• Authors: Andolina, Jeffrey R.; Fries, Carol; Boulware, Renee; Vargas, Alyssa; Fraint, Ellen; Barth, Matthew; Ambrusko, Steven; Comito, Melanie; Monteleone, Philip
• Is Part Of: Journal of pediatric hematology/oncology. Volume 44:Issue 1(2022)
• Page Start: e264
• Page End: e267
• Publication Date: 2021-04-08
• Subjects: bone marrow transplantation -- acute myeloid leukemia -- infant -- pediatric -- CNS; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000002151
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Background: Infant acute myeloid leukemia is a rare but aggressive form of leukemia. Observation: We report 2 children who presented with hyperleukocytosis, subsequently diagnosed with infant acute myeloid leukemia, and both developed isolated central nervous system relapse while on chemotherapy. Both infants underwent successful bone marrow transplantation with myeloablative conditioning (thiotepa, busulfan, and cyclophosphamide) without radiation, followed by 12 empiric post-transplant lumbar punctures with intrathecal cytarabine. Both patients tolerated these therapies well, and are without infections, chronic graft-versus-host disease, or any post-transplant sequelae. Conclusion: Nonradiation-based conditioning followed by empiric central nervous system-directed intrathecal chemotherapy may be considered for high-risk infants with leukemia.