2021 DORIS definition of remission in SLE: final recommendations from an international task force. Issue 1 (24th November 2021)

• Record Type: Journal Article
• Authors: van Vollenhoven, Ronald F; Bertsias, George; Doria, Andrea; Isenberg, David; Morand, Eric; Petri, Michelle A; Pons-Estel, Bernardo A; Rahman, Anisur; Ugarte-Gil, Manuel Francisco; Voskuyl, Alexandre; Arnaud, Laurent; Bruce, Ian N; Cervera, Ricard; Costedoat-Chalumeau, Nathalie; Gordon, Caroline; Houssiau, Frédéric A; Mosca, Marta; Schneider, Matthias; Ward, Michael M; Alarcon, Graciela; Aringer, Martin; Askanase, Anca D; Bae, Sang-Cheol; Bootsma, Hendrika; Boumpas, Dimitrios T; Brunner, Hermine; Clarke, Ann Elaine; Coney, Cindy; Czirják, László; Dörner, Thomas; Faria, Raquel; Fischer, Rebecca; Fritsch-Stork, Ruth; Inanc, Murat; Jacobsen, Søren; Jayne, David; Kuhn, Annegret; van Leeuw, Bernadette; Limper, Maarten; Mariette, Xavier; Navarra, Sandra; Nikpour, Mandana; Olesinska, Marzena Helena; Pons-Estel, Guillermo; Romero-Diaz, Juanita; Rubio, Blanca; Schoenfeld, Yehuda; Bonfá, Eloisa; Smolen, Josef; Teng, Y K Onno; Tincani, Angela; Tsang-A-Sjoe, Michel; Vasconcelos, Carlos; Voss, Anne; Werth, Victoria P; Zakharhova, Elena; Aranow, Cynthia;
• Is Part Of: Lupus science & medicine. Volume 8:Issue 1(2021)
• Publication Date: 2021-11-24
• Subjects: lupus erythematosus -- systemic -- outcome assessment -- healthcare -- therapeutics; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1136/lupus-2021-000538
• Languages: English
• ISSNs: 2398-8851

Abstract

Abstract : Objective: To achieve consensus on a definition of remission in SLE (DORIS). Background: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. Conclusion: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.