Application of molecularly imprinted polymers as artificial receptors for imaging. (1st January 2020)

• Record Type: Journal Article
• Authors: Vaneckova, Tereza; Bezdekova, Jaroslava; Han, Gang; Adam, Vojtech; Vaculovicova, Marketa
• Is Part Of: Acta biomaterialia. Volume 101(2020)
• Page Start: 444
• Page End: 458
• Publication Date: 2020-01-01
• Subjects: Luminescence -- Polymerization -- Microscopy -- Affinity; 2, 4-D 2, 4-dichlorophenoxyacetic acid -- EbAM N, N′-ethylenebis(acrylamide) -- NaPSS poly(sodium 4-styrenesulfonate) -- 4-VP 4-vinylpyridine -- EDOT 3, 4-ethylenedioxythiophene -- NBD nitrobenzoxadiazole -- 4-VPBA 4-vinylphenylboronic acid -- EGDMA ethylene glycol dimethacrylate -- NBDAE 2-[(7-nitro-2, 1, 3-benzoxadiazol-4-yl)amino]ethyl acrylate -- AAB (N-acrylamido)-benzamidine -- EGFR epidermal growth factor receptor -- NIPAAm N-isopropylacrylamide -- AAc acrylic acid -- FITC fluorescein isothiocyanate -- PATP p-aminothiophenol -- AB (4-acrylamidophenyl)(amino)methaniminium acetate -- FL fluorescence -- PBA phenylboronic acid -- ABDV 2, 2′-azobis(2, 4-dimethylvaleronitril) -- FPBA 4-formylphenylboronic acid -- PETRA pentaerythritol triacrylate -- ACVA 4, 4′-azobis (4-cyanovaleric acid) -- Fuc fucose -- PFBT poly(fluorene-alt-benzothiadiazole) -- AEMA 2-aminoethyl methacrylate hydrochloride -- GA glucuronic acid -- PFBT-BO poly(fluorene-alt-benzothiadiazole)-boronic acid -- AIBN 2, 2′-azobisisobutyronitrile -- HaCaT human keratinocytes -- PO-CL peroxyoxalate chemiluminescence -- AM acrylamide -- HeLa human cervix adenocarcinoma cells -- RAFT reversible addition-fragmentation chain transfer -- APBA 3-aminophenylboronic acid -- HEMA poly(2-hydroxyethylmethacrylate) -- Rubpy tris(2, 2′-bipyridine)ruthenium(II) hexafluorophosphate -- APMA N-(3-aminopropyl) methacrylamide hydrochloride -- irr. irradiation -- SA sialic acid -- APS ammonium persulfate -- MAA methacrylic acid -- SiO2 silica shell -- APTES (3-aminopropyl)triethoxysilane -- MAM methacrylamide -- SPR surface plasmon resonance -- BHb bovine hemoglobin -- Man mannose -- TBAm N-tert-butylacrylamide -- BPO benzoyl peroxide -- MBAA N, N'-methylenebisacrylamide -- TEA triethylamine -- CDs carbon nanodots -- MRI magnetic resonance imaging -- TEMED N, N, N', N'-tetramethylethylenediamine -- CP conjugated polymer -- N/A not available -- TEOS tetraethyl orthosilicate -- DMA N, N-dimethylaniline -- NANA N-acetylneuraminic acid -- TRIM trimethylolpropane trimethacrylate -- DMSO dimethyl sulfoxide; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2019.11.007
• Languages: English
• ISSNs: 1742-7061

Abstract

Abstract: Medical diagnostics aims at specific localization of molecular targets as well as detection of abnormalities associated with numerous diseases. Molecularly imprinted polymers (MIPs) represent an approach of creating a synthetic material exhibiting selective recognition properties toward the desired template. The fabricated target-specific MIPs are usually well reproducible, economically efficient, and stable under critical conditions as compared to routinely used biorecognition elements such as fluorescent proteins, antibodies, enzymes, or aptamers and can even be created to those targets for which no antibodies are available. In this review, we summarize the methods of polymer fabrication. Further, we provide key for selection of the core material with imaging function depending on the imaging modality used. Finally, MIP-based imaging applications are highlighted and presented in a comprehensive form from different aspects. Statement of significance: In this review, we summarize the methods of polymer fabrication. Key applications of Molecularly imprinted polymers (MIPs) in imaging are highlighted and discussed with regard to the selection of the core material for imaging as well as commonly used imaging targets. MIPs represent an approach of creating a synthetic material exhibiting selective recognition properties toward the desired template. The fabricated target-specific MIPs are usually well reproducible, economically efficient, and stable under critical conditions as compared to routinely used biorecognition elements, e.g., antibodies, fluorescent proteins, enzymes, or aptamers, and can even be created to those targets for which no antibodies are available. Graphical abstract: Image, graphical abstract Synthetic materials with selective recognition properties toward templates are an alternative to traditionally used recognition biomolecules (e.g., antibodies). Key applications of molecularly imprinted polymers in imaging are highlighted and discussed with regard to the selection of the core material for imaging as well as commonly used imaging targets.