Polar steroid compounds from the Arctic starfish Asterias microdiscus and their cytotoxic properties against normal and tumor cells in vitro. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Kicha, Alla A.; Malyarenko, Timofey V.; Kalinovsky, Anatoly I.; Popov, Roman S.; Malyarenko, Olesya S.; Ermakova, Svetlana P.; Ivanchina, Natalia V.
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 5765
• Page End: 5772
• Publication Date: 2021-12-17
• Subjects: Polyhydroxysteroids -- asterosaponins -- starfish -- Asterias microdiscus -- cytotoxicity -- cell proliferation -- clonogenic assay; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1834551
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new natural compounds, sulfated polyhydroxysteroid, microdiscusol G (1 ), and polyhydroxysteroid bioside, microdiscusoside A (2 ), along with eight previously known polar steroid substances 3–10, were isolated from the Arctic starfish Asterias microdiscus . The structures of 1 and 2 have been elucidated by extensive 1D and 2D NMR spectroscopy and HRESIMS techniques. The 28-sulfooxy-24-methylcholestane side chain in 1 has been found among starfish steroid metabolites for the first time. Steroid saponins 9 and 10 exhibited cytotoxic effects against normal cells JB6 Cl41 and cancer cells HT-29, MDA-MB-231, THP-1, and Raji and effectively suppressed cell proliferation and colony formation of cancer cells HT-29 and MDA-MB-231 in non-toxic concentrations. Compounds 5, 7, and 8 were inactive or less active in the same experiments. Abstract : UF0001