Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae). Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Kayo, Maurice Taboula; Simo, Marguerite Kamdem; Tagatsing Fotsing, Maurice; Talla, Emmanuel; Laurent, Sophie; Elst, Luce Vander; Henoumont, Céline; Yankep, Emmanuel; Alfred Ngenge, Tamfu; Keumoe, Rodrigue; Atchade, Alex de Theodore; Zeukóo, Elisabeth Menkem; Sameza, Modeste Lambert; Roch, Alain; Muller, Robert; Boyom, Fabrice Fekam; Mbafor, Joseph Tanyi
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 5732
• Page End: 5736
• Publication Date: 2021-12-17
• Subjects: Uvaria comperei -- Oxyanthus unilocularis -- -dimethoxy-5H-phenanthridin-6-one -- antifungal activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1828409
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical study of Uvaria comperei afforded an alkaloid, 8, 9-dimethoxy-5 H -phenanthridin-6-one (1 ), isolated and characterised (assignment of 1 H and 13 C NMR) for the first time from a natural source along with two flavonoids, (2S)-5-hydroxy-7, 8-dimethoxyflavanone (2 ) and (2S)-7-hydroxy-5-methoxy-6, 8-dimethylflavone (3 ). Clethric acid (4 ), oleanoic acid (5 ), β-sitosterol 3-O-β-D-glucopyranoside (9 ), β-sitosterol palmitate (6 ) and a mixture of stigmasterol (7 ) and β-sitosterol (8 ) were isolated from Oxyanthus unilocularis . The structures of these compounds were elucidated using modern spectroscopic techniques including1D and 2D Nuclear Magnetic Resonance (NMR) Spectroscopy ( 1 H, 13 C, 1 H- 1 H COSY, HSQC, HMBC) and Mass Spectrometry. Some fractions and compounds from Uvaria comperei exhibited good antifungal activity against clinical isolates and standard strains of yeast species of Candida and Cryptococcus genera while extracts from Oxyanthus unilocularis displayed weak antifungal activity. The results obtained show that Uvaria comperei could be a potential source of antifungal drugs. Graphical Abstract: UF0001