Human Papillomavirus Prevalence and Integration Status in Tissue Samples of Bladder Cancer in the Chinese Population. (17th November 2020)

• Record Type: Journal Article
• Authors: Yan, Yongji; Zhang, Hongfeng; Jiang, Chunfan; Ma, Xin; Zhou, Xueying; Tian, Xun; Song, Yuping; Chen, Xu; Yu, Liyao; Li, Rui; Chen, Hongwei; Wang, Xin; Liu, Ting; He, Zhaohui; Li, Hongzhao
• Is Part Of: Journal of infectious diseases. Volume 224:Number 1(2021)
• Page Start: 114
• Page End: 122
• Publication Date: 2020-11-17
• Subjects: human papillomavirus -- bladder cancer -- HPV prevalence -- HPV distribution -- HPV integration; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa710
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Human papillomavirus (HPV) infection is associated with multiple types of cancer, but the evidence has not yet been fully elucidated in bladder cancer. Methods: Frozen tissue samples collected from 146 patients aged 32 to 89 years with bladder cancer pathological diagnosis between 2015 and 2019 were analyzed. HPV genotyping and integration status determination were performed by capture-based next generation sequencing. Statistical analysis of HPV type distributions was performed according to stage, grade, sex, and age group of patients. Results: Mean (SD) age of the 146 patients was 66.64 ± 10.06 years and 83.56% were men. Overall HPV infection rate was 28.77% (37.50% in women and 27.05% in men), with 11.90% HPV integration events. Among them, 17.12% single and 11.65% coinfections were observed. HPV18 (24.66%) was the most prevalent genotype, followed by HPV33, 16, and 39. All HPV were European lineage (A). HPV16 was more prevalent in women ( P = .04). Conclusions: HPV infection may contribute to the etiology both in men and women with bladder cancer. HPV18, followed by HPV33, 16, and 39 genotypes, potentially represent the predominant oncogenic risk types for bladder carcinogenesis. Abstract : HPV genotyping and integration status determination were performed by capture-based next-generation sequencing in 146 bladder cancer patients in China. HPV infection may contribute a causative role in both men and women with bladder cancer.