Persistence of Maternal Anti-Rotavirus Immunoglobulin G in the Post–Rotavirus Vaccine Era. (19th November 2020)

• Record Type: Journal Article
• Authors: Payne, Daniel C; McNeal, Monica; Staat, Mary Allen; Piasecki, Alexandra M; Cline, Allison; DeFranco, Emily; Goveia, Michelle G; Parashar, Umesh D; Burke, Rachel M; Morrow, Ardythe L
• Is Part Of: Journal of infectious diseases. Volume 224:Number 1(2021)
• Page Start: 133
• Page End: 136
• Publication Date: 2020-11-19
• Subjects: rotavirus -- vaccine -- cohort -- IgG -- immunity -- maternal antibodies; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa715
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: To assess whether titers of anti-rotavirus immunoglobulin G persist during the post–rotavirus vaccine era, the Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal (PREVAIL) Cohort analyzed serum samples collected from Cincinnati-area mothers and young infants in 2017–2018. Rotavirus-specific antibodies continue to be transferred from US mothers to their offspring in the post–rotavirus vaccine era, despite dramatic decreases in childhood rotavirus gastroenteritis. Abstract : The PREVAIL Cohort of US mothers and their offspring found that US infants may continue to be protected against rotavirus gastroenteritis by maternally transferred, naturally acquired passive immunity, more than a decade after implementation of the US rotavirus vaccination program.