Expression of Surfactant Protein D Distinguishes Severe Pandemic Influenza A(H1N1) from Coronavirus Disease 2019. (1st May 2021)

• Record Type: Journal Article
• Authors: Choreño-Parra, José Alberto; Jiménez-Álvarez, Luis Armando; Ramírez-Martínez, Gustavo; Cruz-Lagunas, Alfredo; Thapa, Mahima; Fernández-López, Luis Alejandro; Carnalla-Cortés, Martha; Choreño-Parra, Eduardo M; Mena-Hernández, Lourdes; Sandoval-Vega, Montserrat; Hernández-Montiel, Erika Mariana; Hernández-García, Diana Lizzeth; Ramírez-Noyola, Jazmín Ariadna; Reyes-López, Cynthia Estefania; Domínguez-Faure, Andrea; Zamudio-López, Guillermo Yamil; Márquez-García, Eduardo; Moncada-Morales, Angélica; Mendoza-Milla, Criselda; Cervántes-Rosete, Diana; Muñoz-Torrico, Marcela; Luna-Rivero, Cesar; García-Latorre, Ethel A; Guadarrama-Ortíz, Parménides; Ávila-Moreno, Federico; Domínguez-Cherit, Guillermo; Rodríguez-Reyna, Tatiana Sofía; Mudd, Philip A; Hernández-Cárdenas, Carmen Margarita; Khader, Shabaana A; Zúñiga, Joaquín;
• Is Part Of: Journal of infectious diseases. Volume 224:Number 1(2021)
• Page Start: 21
• Page End: 30
• Publication Date: 2021-05-01
• Subjects: SARS-CoV-2 -- COVID-19 -- influenza A(H1N1)pdm09 -- acute respiratory distress syndrome -- surfactant protein D; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab113
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: The differentiation between influenza and coronavirus disease 2019 (COVID-19) could constitute a diagnostic challenge during the ongoing winter owing to their clinical similitude. Thus, novel biomarkers are required to enable making this distinction. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in patients with severe pandemic influenza but not those with COVID-19. This finding was validated in a separate cohort of mechanically ventilated patients with COVID-19 who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with death and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19. Abstract : In this study, the authors found that serum surfactant protein D (SP-D) levels are increased in critically ill patients with pandemic influenza A(H1N1) and serve to differentiate them from individuals with severe coronavirus disease 2019 (COVID-19).