The Aldol Reaction of α‐Ketoamide with α, β‐Unsaturated Ketone in KOH Aqueous Medium. Issue 4 (24th January 2022)

• Record Type: Journal Article
• Authors: Qin, Xin; Wu, Chaofei; Lu, Fanyun; Wang, Zhan‐Yong; Jiang, Jun; Liu, Hongxin
• Is Part Of: ChemistrySelect. Volume 7:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-24
• Subjects: Aldol reaction -- α-Ketoamide -- α, β-Unsaturated ketone -- Hydroxylation -- KOH catalyzed; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202104146
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Herein, we report for the first time the aldol reaction of a wide range of α‐ketoamide with α, β‐unsaturated ketone via the activation of potassium hydroxide in aqueous medium. The protocol provides a straightforward and atom‐efficient strategy for the synthesis of a new family of multifunctional α‐hydroxy amides contain α, β‐unsaturated ketone group from easily accessible substituted α‐ketoamide and α, β‐unsaturated ketone. The reaction features mild reaction conditions, green solvent, one of which is quaternary carbon substitution. The method can accommodate various substituents and substitution patterns, afford the products up to 95 % yields. Abstract : An aldol reaction of α‐ketoamide with α, β‐unsaturated ketone for the construction of α‐hydroxy amides derivatives with quaternary carbon substitution in aqueous medium by KOH catalyzed up to 95 % yeild was reported.