Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population. Issue 1 (5th August 2020)

• Record Type: Journal Article
• Authors: Zhou, Xiaopu; Chen, Yu; Ip, Fanny C. F.; Lai, Nicole C. H.; Li, Yolanda Y. T.; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M. N.; Cheung, Kit; Tong, Estella P. S.; Ko, Ho; Shoai, Maryam; Mok, Kin Y.; Hardy, John; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Fu, Amy K. Y.; Ip, Nancy Y.
• Is Part Of: Alzheimer's & dementia. Volume 12:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-05
• Subjects: Alzheimer's disease -- disease risk -- polygenic risk score -- population genetics -- SORL1; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1002/dad2.12074
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: Dozens of Alzheimer's disease (AD)‐associated loci have been identified in European‐descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population. Methods: TaqMan array genotyping was performed for known AD‐associated variants in a Hong Kong Chinese cohort. Regression analysis was conducted to study the associations of variants with AD‐associated traits and biomarkers. Lasso regression was applied to establish a polygenic risk score (PRS) model for AD risk prediction. Results: SORL1 is associated with AD in the Hong Kong Chinese population. Meta‐analysis corroborates the AD‐protective effect of the SORL1 rs11218343 C allele. The PRS is developed and associated with AD risk, cognitive status, and AD‐related endophenotypes. TREM2 H157Y might influence the amyloid beta 42/40 ratio and levels of immune‐associated proteins in plasma. Discussion: SORL1 is associated with AD in the Hong Kong Chinese population. The PRS model can predict AD risk and cognitive status in this population.