Induced pluripotent stem cell‐derived extracellular vesicles: A novel approach for cell‐free regenerative medicine. Issue 6 (27th November 2018)

• Record Type: Journal Article
• Authors: Taheri, Behnaz; Soleimani, Masoud; Fekri Aval, Sedigheh; Esmaeili, Elaheh; Bazi, Zahra; Zarghami, Nosratollah
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 6(2019:Jun.)
• Page Start: 8455
• Page End: 8464
• Publication Date: 2018-11-27
• Subjects: cell therapy -- extracellular vesicles -- induced pluripotent stem cells -- regenerative medicine; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.27775
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: In recent years, induced pluripotent stem cells (iPSCs) have been considered as a promising approach in the field of regenerative medicine. iPSCs can be generated from patients' somatic cells and possess the potential to differentiate, under proper conditions, into any cell type. However, the clinical application of iPS cells is restricted because of their tumorigenic potential. Recent studies have indicated that stem cells exert their therapeutic benefit via a paracrine mechanism, and extracellular vesicles have been demonstrated that play a critical role in this paracrine mechanism. Due to lower immunogenicity, easier management, and presenting no risk of tumor formation, in recent years, researchers turned attention to exosomes as potential alternatives to whole‐cell therapy. Application of exosomes derived from iPSCs and their derived precursor provides a promising approach for personalized regenerative medicine. This study reviews the physiological functions of extracellular vesicles and discusses their potential therapeutic benefit in regenerative medicine. Abstract : Extracellular vesicles contribute to the therapeutic effect of the stem cells, including stimulation of organ repair. The discovery of induced pluripotent stem cells represented a promising source for autologous extracellular vesicles generation to use in regenerative medicine.