Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos. Issue 6 (22nd December 2020)

• Record Type: Journal Article
• Authors: Agudelo, Christian; Tarraf, Wassim; Wu, Benson; Wallace, Douglas M.; Patel, Sanjay R.; Redline, Susan; Kaur, Sonya; Daviglus, Martha; Zee, Phyllis C.; Simonelli, Guido; Mossavar‐Rahmani, Yasmin; Sotres‐Alvarez, Daniela; Zeng, Donglin; Gallo, Linda C.; González, Hector M; Ramos, Alberto R.
• Is Part Of: Alzheimer's & dementia. Volume 17:Issue 6(2021)
• Page Start: 959
• Page End: 968
• Publication Date: 2020-12-22
• Subjects: actigraphy -- cognitive decline -- cohort studies -- Hispanic/Latinos -- risk factors in epidemiology -- sleep; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12250
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: We determined if actigraphy‐derived sleep patterns led to 7‐year cognitive decline in middle‐aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep‐onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep‐onset latency was also cross‐sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle‐aged Hispanic/Latinos, actigraphy‐derived sleep‐onset latency predicted 7‐year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.