Magnolol induces apoptosis in osteosarcoma cells via G0/G1 phase arrest and p53‐mediated mitochondrial pathway. Issue 10 (3rd June 2019)

• Record Type: Journal Article
• Authors: Zhou, Siqi; Wen, Haiyan; Li, Haohuan
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 10(2019)
• Page Start: 17067
• Page End: 17079
• Publication Date: 2019-06-03
• Subjects: apoptosis -- magnolol -- mitochondria -- osteosarcoma -- p53; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28968
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Osteosarcoma is a highly invasive primary malignancy of bone. Magnolol is biologically active, which shows antitumor effects in a variety of cancer cell lines. However, it has not been elucidated magnolol's effects on human osteosarcoma cells (HOC). This study aimed to determine antitumor activity of magnolol and illustrate the molecular mechanism in HOC. Magnolol showed significant inhibition effect of growth on MG‐63 and 143B cells and induced apoptosis and cell cycle arrest at G0/G1. In osteosarcoma cells, magnolol upregulated expressions of proapoptosis proteins and suppressed expressions of antiapoptosis proteins. Additionally, under the pretreatment of pifithrin‐a (PFT‐a, a p53 inhibitor), the magnolol‐induced apoptosis was significantly reversed. The results above indicated that magnolol induces apoptosis in osteosarcoma cells may via G0/G1 phase arrest and p53‐mediated mitochondrial pathway. Abstract : Magnolol induces apoptosis in osteosarcoma cell cycle arrest at G0/G1 phase p53‐mediated mitochondrial pathway.