Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease. Issue 1 (11th November 2020)

• Record Type: Journal Article
• Authors: Sone, Daichi; Shigemoto, Yoko; Ogawa, Masayo; Maikusa, Norihide; Okita, Kyoji; Takano, Harumasa; Kato, Koichi; Sato, Noriko; Matsuda, Hiroshi
• Is Part Of: Alzheimer's & dementia. Volume 12:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-11
• Subjects: Alzheimer's disease -- molecular imaging -- neurodegeneration -- neuroinflammation -- orientation dispersion and density imaging -- tau; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1002/dad2.12125
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: The molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in Alzheimer's disease (AD) research. Methods: We recruited 27 amyloid‐positive individuals identified through 11 C‐Pittsburgh compound B (PiB) positron emission tomography (PET) and 31 amyloid‐negative individuals with normal cognition. All participants underwent 11 C‐PiB and 18 F‐THK5351 PET and magnetic resonance imaging (MRI) with neurite orientation dispersion and density imaging (NODDI) protocol. The neurite density index (NDI), orientation dispersion index (ODI), and PET images were analyzed to calculate voxel‐wise correlations among the imaging modalities and correlations with cognitions. Results: In the amyloid‐positive participants, there were significant negative correlations between 18 F‐THK5351 and NDI and between 18 F‐THK5351 and ODI. The bilateral mesial and lateral temporal lobes were mainly involved. Regarding cognition, 18 F‐THK5351 showed more marked associations with all cognitive domains than the other modalities. Discussion: Tau and neuroinflammation in AD may reduce the neurite density and orientation dispersion, particularly in the mesial and lateral temporal lobes.