The PINK1 repertoire: Not just a one trick pony. (7th October 2021)
- Record Type:
- Journal Article
- Title:
- The PINK1 repertoire: Not just a one trick pony. (7th October 2021)
- Main Title:
- The PINK1 repertoire: Not just a one trick pony
- Authors:
- Pollock, Liam
Jardine, Jane
Urbé, Sylvie
Clague, Michael J. - Abstract:
- Abstract: PTEN‐induced kinase 1 (PINK1) is a Parkinson's disease gene that acts as a sensor for mitochondrial damage. Its best understood role involves phosphorylating ubiquitin and the E3 ligase Parkin (PRKN) to trigger a ubiquitylation cascade that results in selective clearance of damaged mitochondria through mitophagy. Here we focus on other physiological roles of PINK1. Some of these also lie upstream of Parkin but others represent autonomous functions, for which alternative substrates have been identified. We argue that PINK1 orchestrates a multi‐arm response to mitochondrial damage that impacts on mitochondrial architecture and biogenesis, calcium handling, transcription and translation. We further discuss a role for PINK1 in immune signalling co‐ordinated at mitochondria and consider the significance of a freely diffusible cleavage product, that is constitutively generated and degraded under basal conditions. Abstract : The Parkinson's disease‐related protein PINK1 has a well‐established role in promoting mitophagy of damaged mitochondria. Here, Pollock et al . highlight a broader landscape of PINK1‐associated cell physiology. This includes other key aspects of mitochondrial homeostasis and damage sensing, as well as immune and calcium signalling.
- Is Part Of:
- BioEssays. Volume 43:Number 11(2021)
- Journal:
- BioEssays
- Issue:
- Volume 43:Number 11(2021)
- Issue Display:
- Volume 43, Issue 11 (2021)
- Year:
- 2021
- Volume:
- 43
- Issue:
- 11
- Issue Sort Value:
- 2021-0043-0011-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2021-10-07
- Subjects:
- ISR -- mitochondria -- mitochondrial quality control -- mitophagy -- Parkin -- Parkinson's disease -- PINK1 -- stress response
Molecular biology -- Periodicals
Cytology -- Periodicals
Developmental biology -- Periodicals
572.8 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/bies.202100168 ↗
- Languages:
- English
- ISSNs:
- 0265-9247
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2072.118000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 25846.xml